Basel, Switzerland
Internship Explorer
Internship Explorer
High-throughput drug screening has traditionally relied on 2D cell culture systems, which often fail to capture the structural and metabolic complexity of in vivo patient tumors. This project aims to overcome that limitation by extending our high-throughput metabolic fingerprinting platform into 3D cancer models such as spheroids and organoids. By combining untargeted metabolomics, high-content imaging, and computational modelling, we will systematically compare how 320 small molecules reshape metabolism in both 2D and 3D environments. The resulting dataset will reveal which drug-induced metabolic programs are shared between dimensional contexts and which emerge uniquely in physiologically relevant 3D systems. Ultimately, this work will generate a high-impact resource that improves mechanistic drug profiling and informs model selection across cancer research and drug discovery. In line with our and Uni Basel values (https://www.unibas.ch/en/Research/Values-Ethics/Diversity.html), we are committed to sustain and promote an inclusive culture, ensure equal opportunities and value diversity and respect in our working and learning environment. We are seeking a highly motivated 100% Research Intern to support the development, benchmarking, and large-scale profiling of 3D cancer models within our multidisciplinary team. The ideal candidate is enthusiastic about experimental work, data-driven discovery, and collaborative problem-solving.
