Basel, Switzerland
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The candidate will join our multi-disciplinary team and focus on the development and performance of modern assays to evaluate bioactive molecules targeting major signaling pathways in cancer and inflammation. Projects: Main focus: * Targeting oncogenicity by covalent inhibitors, a project with a translational aspect. For relevant recent publications see Borsari et al. (2022) J. Am. Chem. Soc. 144(14): 6326–6342; Bissegger et al. (2024) Chem. Sci. 15: 20274-20291 This project is flanked by a basic research project developing novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism. For a summary of the latter see: p3.snf database * In parallel we investigate the role of PI3K in allergy, metabolic control, obesity, diabetes and cancer. * To design, execute and analyze biochemical, biophysical and cellular drug screening assays to evaluate small molecule inhibitors. * Assays include imaging, TR-FRET, inhibitor/target interaction studies, cell culture, automated nanoLt dispensing and more. * Subsequent analysis of results requires GraphPad Prism, KinTek Explorer (kinetic analysis), Excel, and Statistics. * Work in a multi-disciplinary environment collaborating with cell biologists and chemists. * Writing of reports and protocols.
